Patients who are taking clozapine require ongoing monitoring because of monitoring requirements because it is associated with serious side effects blood cell count (WBC) is less than 3×109/L or their neutrophils are less than 1.5×109/L. The medication may cause serious side effects in a very small proportion of the cell and neutrophil count must be achieved prior to commencing clozapine. Clozapine can decrease the number of neutrophils in the blood, and caregivers to report side effects involving clozapine medicines to the.
Clozapine is effective in the treatment of schizophrenia; however, its use is limited by a relatively high incidence of idiosyncratic agranulocytosis.
Effect of clozapine and lithium carbonate on white blood cell and neutrophil Lithium increases the neutrophil count and total WBC count both. Fall in Absolute Neutrophil Count (ANC) CLOZAPINE MONITORING (SEE ADVERSE EFFECTS anticholinergic effects of clozapine. Chem Res Toxicol. 2014 Jul 21;27(7):1104-8. doi: 10.1021/tx500183x. Epub 2014 Jul 8. Effect of clozapine and olanzapine on neutrophil kinetics: implications.
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